Photochemical internalisation as a novel strategy to enchance efficacy of antibiotics against intracellular infections

A variety of bacteria such as Staphylococcus aureus and Staphylococcus epidermidis can survive in host cell, even in phagocystes (e.g. macrophages) after phagocytosis, causing intracellular infections. Treatment of this intracellular infections often fails due to the low intracellular efficacy of most conventional antimicrobials such as antibiotics. Thus, novel techniques that can improve intracellular efficacy of antibiotics are highly needed. Poster presented by Xiaolin Zhang during

Developing a multi-functionalized endotracheal tube to fight polymicrobial biofilms in a novel artificial ventilator-associated pneumonia model

THE POLY-PREVENTT project poster presented during the AMiCI Workshop for Early Career Investigators (ECIs) and Short Term Scientific Missions (STSM). Riga, Latvia, 7th of March 2019 by Suzana Lopez.

Effect of shear stress on the reduction of bacterial adhesion to antifouling polymers

In this work, two antifouling polymer brushes were tested at different shear stress conditions to evaluate their performance in reducing the initial adhesion of Escherichia coli. Assays were performed using a parallel plate flow chamber and a shear stress range between 0.005 and 0.056 Pa, previously determined by numerical simulation. These shear stress valuesare found in different locations in the human body where biomedical devices

Evaluation of edible chitosan coatings on shelf life and control of Listeria monocytogenes of meat and ready-to-eat meat products

Papadopoulos Panagiotis 2019 Chitosan is a natural, nontoxic, biodegradable biopolymer which derives by the deacetylation of chitin, a main component of the shells of crustaceans such shrimp, crab and crawfish. Chitosan as well as it’s oligomers, receive considerable attention due to their antimicrobial, antitumor and hypocholesterolemic abilities. Chitosan based edible coating and films, incorporated or not with other antimicrobial agents (essential oils, lauric alginate, ester,

Dealing with metal emmission quantification on LCA as a proxy for coating ingredients

We focus on the fate and effects of metals from anthropogenic sources; applying life cycle assessment (LCA) approach to characterize and evaluate the potential environmental impacts of metal-specific emissions. Advance the quantification methods to assess metal toxicity to be able to explain different environmental impact profiles in the frame of LCA studies, and establish clear guidelines to account for emissions in the inventory evaluation of

Surface properties of antibacterial materials based on collagen nad thymol

Collagen is a polymer that naturally occurs in the human body, and due to its characteristic properties such as biocompatibility, and nontoxicity is commonly used in the biomedical and cosmetic field. Thymol is a monoterpene phenol which shows many biological activities, such as antimicrobial, antioxidant, anti-inflammatory and local antiseptic [1]. Prepared collagen/thymol material showed antibacterial properties [2]. In this study, surface properties of this material

Microplates for simulating biofilms formed in medical devices

Biofilms are problematic in the health sector since they are responsible for 65% of the hospital acquired infections associated with medical devices. Hydrodynamics have a very strong influence in the process of biofilm formation.Flow behavior in 96-well microtiter plates (MTPs) was simulated for shaking frequencies between 50 and 200 rpm and diameters from 25 to 100 mm. Shear strain values up to 150s-1 were obtained.

Evaluation of bacterial adhesion on pelvic floor implants: important considerations regarding experimental set-up

Within the field of urogynecology there is an urge to develop an optimal biocompatible implant for the improvement of surgical repair of pelvic organs prolapse. Bacterial contamination of the implant seems unavoidable during surgery. Even after infection prophylaxes, the vagina is colonized with different bacterial species, with Staphylococcus aureus being one of the most common. Subclinical contamination of the implant is important since complications are

Antimicrobial activity of polylactic acid nanofibers

The objectives: the fabrication of phytochemical based antimicrobial nanofiber composites via electrospinning Polylactic acid (PLA) used for the nanofiber fabrication. Tannic acid used as antimicrobial agent. The antimicrobial activity of the composites assessed against Escherichia coli. Poster presented during the AMiCI Workshop for Early Career Investigators (ECIs) and Short Term Scientific Missions (STSM). Riga, Latvia, 7th of March 2019

Exploring Polydopamine-based Coating Strategies to boost Chlorohexidine immobilization for the Development of an Antimicrobial Surface

Orthopedic implants have been widely used to restore the function of load-bearing joints, reducing pain and improving the life quality of millions of people every year. These devices are, however, prone to microbial infection, which remains a major cause of morbidity and mortality in modern Healthcare. The development of novel approaches to confer the surfaces of orthopedic implants with anti-infective properties is, therefore, in great